在事件KeyDown和KeyUp中有个Shift。要判断Ctrl键是否按下，使用该常数。该参数用作位屏蔽。它可被用来测试任何键组合。CtrlDown = (Shift And VbCtrlMask) > 0ShiftDown = (Shift And vbShiftMask) > 0AltDown = (Shift And VbAltMask) > 0用命令按下和松开Ctrl键：使用API函数keybd_event。Const VK_CONTROL = &H11Const KEYEVENTF_EXTENDEDKEY = &H1Const KEYEVENTF_KEYUP = &H2Private Declare Sub keybd_event Lib "user32" Alias "keybd_event" (ByVal bVk As Byte, ByVal bScan As Byte, ByVal dwFlags As Long, ByVal dwExtraInfo As Long)这个函数模拟了键盘行动bVk Byte，欲模拟的虚拟键码，API中定义了一些键值，用API Text View看看是否有你需要的。bScan Byte，键的OEM扫描码 dwFlags Long，零；或设为下述两个标志之一： KEYEVENTF_EXTENDEDKEY 指出是一个扩展键，而且在前面冠以0xE0代码 KEYEVENTF_KEYUP 模拟松开一个键 dwExtraInfo Long，通常不用的一个值。使用的时候一般没管，填0下面的代码是打开一个记事本，并发送Ctrl+O，使打开文件对话框出现Const VK_CONTROL = &H11Const KEYEVENTF_EXTENDEDKEY = &H1Const KEYEVENTF_KEYUP = &H2Private Declare Sub keybd_event Lib "user32" (ByVal bVk As Byte, ByVal bScan As Byte, ByVal dwFlags As Long, ByVal dwExtraInfo As Long)Private Sub Form_Load() Shell "notepad.exe", vbNormalFocus '运行记事本程序 keybd_event VK_CONTROL, 0, 0, 0 '按下Ctrl键 keybd_event vbKeyO, 0, 0, 0 '按下字母O键 keybd_event VK_CONTROL, 0, KEYEVENTF_KEYUP, 0 '放开Ctrl键 keybd_event vbKeyO, 0, KEYEVENTF_KEYUP, 0 '放开字母O键End Sub